Wydase Injectable may also be used for purposes not listed in this medication guide. Wydase Injectable contains Hyaluronidase as an active ingredient. Detailed information related to Wydase Injectable's uses, composition, dosage, side effects and reviews is listed below.
Report your Use ». Learn more: Uses. Side-effects The following is a list of possible side-effects that may occur from all constituting ingredients of Wydase Injectable. This is not a comprehensive list. These side-effects are possible, but do not always occur. Some of the side-effects may be rare but serious. Consult your doctor if you observe any of the following side-effects, especially if they do not go away.
If you notice other side-effects not listed above, contact your doctor for medical advice. You may also report side-effects to your local food and drug administration authority. Report Side-effects ». Precautions Before using Wydase Injectable , inform your doctor about your current list of medications, over the counter products e.
Some health conditions may make you more susceptible to the side-effects of the drug. Take as directed by your doctor or follow the direction printed on the product insert. Dosage is based on your condition.
Tell your doctor if your condition persists or worsens. Important counseling points are listed below. If you are pregnant, planning to become pregnant, or are breastfeeding If you have a skin infection or skin cancer Inform your doctor if you have impaired renal function. Interactions with Wydase Injectable If you use other drugs or over the counter products at the same time, the effects of Wydase Injectable may change.
This may increase your risk for side-effects or cause your drug not to work properly. Tell your doctor about all the drugs, vitamins, and herbal supplements you are using, so that you doctor can help you prevent or manage drug interactions.
Wydase Injectable may interact with the following drugs and products:. In addition, Wydase Injectable should not be used if you have the following conditions:. Cancer Direct application in eye Hypersensitivity.
Composition and Active Ingredients Wydase Injectable is composed of the following active ingredients salts. Please note that this medicine may be available in various strengths for each active ingredient listed above. As a control for the diluent volume administered with the hyaluronidase injection, the effect of a circumferential injection of 1.
Again, the area of skin necrosis following injection with hyaluronidase was statistically smaller P less than. We have created a reliable skin injury model using immature porcine skin, which resembles human skin. As the side effects of fillers on blood vessels are known, many attempts have been made to effectively dissolve fillers inside blood vessels. DeLorenzi [ 3 ] concluded in a paper that hyaluronidase could be injected subcutaneously without the need for intravascular injections to treat filler-induced vascular embolism.
In an animal experiment, Wang et al. The amount of hyaluronidase is important when injecting hyaluronidase in the vicinity of a blood vessel to dissolve filler inside the vessel. Lee et al. Local injections of hyaluronidase can cause side effects such as local pruritus and allergic reactions. The incidence of allergic reactions is reported to be 0. Allergic reactions are more likely to occur when the hyaluronidase dose is more than , IU through an intravenous injection, and the occurrence of allergic complications rises to Most allergic reactions of hyaluronidase are immediate hypersensitivity reactions type I, immunoglobulin E—mediated , but delayed hypersensitivity reactions type IV, T-cell—mediated may also occur [ 17 ].
Immediate hypersensitivity reactions caused by hyaluronidase manifest as erythematous edema after 1 to 2 hours, and there is no response to antibiotic treatment. In such cases, systemic steroids, antihistamines, and steroid cream application are helpful [ 17 ]. Delayed hypersensitivity reactions caused by hyaluronidase can occur even after 24 hours, and in such cases, a skin test will not produce a positive reaction within 20 minutes, resulting in a negative diagnosis [ 18 ].
The skin test is performed with 3 IU of hyaluronidase; although is recommended to perform a skin test before using hyaluronidase, doing so can often be difficult in general clinics [ 17 ]. However, depending on the origin of hyaluronidase, injection of hyaluronidase should be avoided because cross-reactions may occur in patients who are allergic to bovine collagen and bee stings [ 1 ].
Hyaluronidase use has become more diverse and widespread in clinical practice. As its use becomes more common, it is increasingly important for clinicians to have a sufficient knowledge of hyaluronidase. Hyaluronidase can serve as an appropriate treatment in a variety of situations if it is used with a thorough understanding of its mechanism of action, metabolism, and side effects. Conflict of interest. No potential conflict of interest relevant to this article was reported.
National Center for Biotechnology Information , U. Journal List Arch Plast Surg v. Arch Plast Surg. Published online Jul Hyunwook Jung. Author information Article notes Copyright and License information Disclaimer. This article has been cited by other articles in PMC. Abstract Hyaluronidase, an enzyme that breaks down hyaluronic acid, has long been used to increase the absorption of drugs into tissue and to reduce tissue damage in cases of extravasation of a drug.
Keywords: Hyaluronidase, Hyaluronic acid, Filler. Open in a separate window. Footnotes Conflict of interest No potential conflict of interest relevant to this article was reported. Changing role of hyaluronidase in plastic surgery. Plast Reconstr Surg. The role of hyaluronidase in the treatment of complications from hyaluronic acid dermal fillers. Aesthet Surg J. DeLorenzi C. Transarterial degradation of hyaluronic acid filler by hyaluronidase. Dermatol Surg.
Hyaluronidase in the correction of hyaluronic acid-based fillers: a review and a recommendation for use. J Cosmet Dermatol.
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